![]() Many substances and conditions can lead to pulmonary fibrosis. Lung damage can also result from a number of conditions, including: Certain anti-inflammatory drugs such as rituximab (Rituxan) or sulfasalazine (Azulfidine) can cause lung damage. Antibiotics such as nitrofurantoin (Macrobid, Macrodantin, others) or ethambutol can cause lung damage. Some drugs used to treat irregular heartbeats, such as amiodarone (Cordarone, Nexterone, Pacerone), may harm lung tissue. Drugs designed to kill cancer cells, such as methotrexate (Trexall, Otrexup, others) and cyclophosphamide, can also damage lung tissue. Many drugs can damage your lungs, especially medications such as: The presence of underlying lung disease.The total amount of radiation administered.How much of the lung was exposed to radiation.The severity of the damage may depend on: Some people who receive radiation therapy for lung or breast cancer show signs of lung damage months or sometimes years after the initial treatment. Long-term exposure to a number of toxins and pollutants can damage your lungs. The damage can be caused by many different factors - including long-term exposure to certain toxins, certain medical conditions, radiation therapy and some medications. This makes it more difficult for oxygen to pass into your bloodstream. Pulmonary fibrosis scars and thickens the tissue around and between the air sacs (alveoli) in your lungs.
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